Prostate cancer is the most common cancer diagnosed in Canadian men.The standard method used to detect prostate cancer involves an ultrasound probe being inserted into the rectum and needle biopsies piercing the rectal wall to take tissue samples from the prostate. This procedure is uncomfortable, has significant risks of infection and occasionally does not accurately detect prostate cancer. The purpose of this study is to investigate a novel method of prostate biopsy using a state of the art computerized guidance system. Cancer within the prostate is not accurately detected by CT. Prostate cancer can be accurately detected by MRI. However, the metal components used to perform biopsies cannot be placed in an MRI machine. Our novel method of prostate biopsy involves using a new computerized technology that permits a lesion detected on MRI to be projected by a computer into 3 dimensions on a patient’s CT scan. A CT guided biopsy can then be performed where a needle is advanced into the patient, where the computer has projected the image of the tumor that cannot normally be seen on CT. We plan to compare this new method of prostate biopsy to the currently employed standard prostate biopsy technique.