Prostate cancer is the most common non-‐skin cancer in men. It can take years to progress and most patients die of other causes. But in some, prostate cancer is more aggressive and can be rapidly fatal. Identifying aggressive prostate cancer requiring immediate attention is critical for patient management. One factor in prostate cancer is the myc gene, which when deranged, can make it aggressive. We have found a novel chemical synergy between deranged myc and a protein called Pygopus2, which we think is exploited by actively growing cancer cells. Understanding this mechanism provides necessary information to design new therapies.